Abstract
Many international toxicology and fertility studies confirm that the “Gold Standard” sperm chromatin structure assay (SCSA) is the most rapid, technician-friendly, and statistically robust test on 5000 sperm/semen samples to determine whether any suspected toxicant is causing sperm DNA damage. Even though the exact causes and origin of sperm DNA damage may be unknown, the established SCSA thresholds for in vivo, intrauterine insemination (IUI), in vitro fertilization, and intracytoplasmic sperm injection (ICSI) success strongly support an increasingly routine use of the SCSA test in the toxicology/urology and infertility clinics. Numerous toxicology studies, mostly in animals, clearly show that the SCSA test is a very sensitive assay to detect damage to sperm DNA that impacts successful pregnancy. SCSA-derived 0%–20% DFI (% sperm in an ejaculate with sperm DNA fragmentation), with normal WHO semen parameters, is consistent with excellent odds for in vivo or IUI conception; decreasing odds occur between 20% and 30% DFI at which point in vivo and IUI have very poor odds and ICSI is recommended. At >40% DFI the odds are very low for pregnancy and higher for miscarriage.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Bioenvironmental Issues Affecting Men’s Reproductive and Sexual Health
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
