Abstract
Cerebral vascular disorders refer to the diminution in flow of blood to the central nervous system and include all ailments which affect the particular portion of the brain either due to ischemia or hemorrhage. These comprise serious dysfunction of central nervous system like carotid stenosis, vertebral stenosis and intracranial stenosis, aneurysms, vascular malformations and stroke. In general, the pathophysiology sequel the involvement of one or more of the cerebral blood vessels engendering narrowing of vessels, clot formation, blockage or rupture of blood vessels. Deficiency in blood flow, affecting temporarily to the brain tissue may cause a transient ischaemic attack.If the blockage is prolonged, it may give rise to more deadly stroke. This chapter provides an overview on recent medical, surgical, and endovascular interventions for the treatment and management of cerebrovascular disorders. Broadly these approaches include physiological, invasive, pharmacological and chemical, ethosomes, prodrugs, genetic material delivery and bioengineering. The ultimate aim is to maneuver nanocarriers and non-nanoparticles containing the therapeutic agents into the brain via both normal and disarranged blood brain barrier.
Published Version
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