Abstract
Actinobacteria are important sources for discovery of secondary metabolites for application in medicine and agriculture. Genome mining methods employ combinations of molecular biology techniques, including next-generation sequencing, and bioinformatics-based methods reinvigorating interest in the biosynthetic potential of gene clusters in actinobacteria, opening new avenues for the discovery of natural bioactive products. Notwithstanding the recent advancements in genomics, the field of natural products research is currently undergoing a paradigm shift. However, recent insights gained from genomics revealed a massive existence of previously unrecognized biosynthetic potential in actinobacteria. Interestingly genomics-guided natural product discovery is considered a feasible approach for the discovery of novel and bioactive secondary metabolites from the actinobacteria. In this review an attempt is made to highlight novel perspectives in natural product genomics, and analyze the strengths and limitations of the genomics technology, where elucidation of certain aspects could lead to noteworthy biotechnological applications.
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