Abstract
Recent advances in single-cell technologies have enabled the profiling of epigenetic landscapes of individual cells, opening a powerful new means for understanding regulatory changes that occur in cancer and cancer-adjacent tissues. In this review, we give an overview of single-cell epigenetic measurement technologies, describe how they have been used in cancer-related studies, highlight their associated challenges, and describe practical considerations for single-cell epigenetic analysis—from cell preparation to data analysis. Finally, we delineate open questions in cancer epigenetic research ripe for investigation with single-cell methods and their corresponding analytical challenges.
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