Abstract
This chapter outlines the genetic and cellular evidence demonstrating how condensations of progenitor cells differentiate into chondroblasts or osteoblasts. Control of condensation growth is analysed using studies from limb buds of talpid mutant chick embryos, and studies on the importance of gap junctional connections, fibronectin and hyaluronan. Sox9, Hoxa2 and Hoxa13 regulate the transition to chondrogenesis, Runx2 and Osterix regulate the transition to osteogenesis.
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