Abstract
In the recent years, genome-wide analyses have been used to characterize the genetic landscapes of many cancers. One of the most frequent classes of genes found to be mutated is the epigenetic regulators, providing a link between genetic alterations and epigenetic changes in cancer. In addition, multiple studies have reported aberrant DNA and histone methylation patterns in cancer. The recognition of the mutuality between genetic and epigenetic aberrations in cancer and the reversible features of epigenetic changes provide a rationale for combining epigenetic therapy with conventional chemotherapy and form basis for the development of novel and targeted treatment modalities. The focus of this chapter is to review aberrant DNA methylation and hydroxymethylation patterns in cancer, mutations in epigenetic regulators involved in DNA methylation maintenance fidelity, and the driving events in the process of DNA methylation in tumorigenesis.
Published Version
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