Abstract
Viral infections are a major health problem worldwide and they are responsible for the high rate of mortality. Most of the drugs used to treat viral infections suffer from drug resistance and toxicity. To overcome the drug resistance, the antiviral drugs are administered in combination of two or more for enhanced therapeutic efficacy. Furthermore, the use of drug delivery systems and the development of hybrid molecules containing two or more antiviral drugs has been reported by several researchers as potential approaches for the development of effective antiviral agents. Metal-based nanoparticles are also effective against viral infections, revealing their potential application for the development of antiviral agents. This chapter reports the efficacy of hybrid molecules, drug delivery systems incorporated with antiviral agents, and metal-based nanoparticles in the treatment of viral infections.
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