Abstract
Current treatment of brain cancer is hampered by few effective treatment options and characterized by low survival rates. Some advanced drug delivery systems carrying small molecules are currently being developed and may have a major positive impact in the overall outcomes of the treatment regimens. We will discuss the benefits of liposomal formulations, the most commonly used nanoparticles for drug delivery. Liposomal formulation of chemotherapeutics can improve the efficacy and reduce the side effects of the chemotherapy by improving the drug release, pharmacokinetic and biodistribution profile. Uptake of these nanoparticles into the brain is however limited due to the presence of a blood–brain and blood–tumor barrier. By combining safe targeting ligands and receptors with well-known and safe nanocarrier technologies, brain-targeted liposomes may overcome these barriers and result in new and effective chemotherapeutic drugs for clinical use. Examples and practical issues involved in liposomal formulation of chemotherapeutics are discussed.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
