Chapter 18 - Novel targeting strategies on signaling pathways of colorectal cancer

Abstract

Among the most lethal cancers in the world, the rate of colorectal cancer (CRC) increases as on rise in the rate of incidence so the mortality rate also rises, which shows a serious effect on general public health. The causes and progression of CRC have been linked to many molecular pathways. This chapter will concentrate on the various. The primary signaling pathways associated with the development of CRC, including epidermal growth factor receptor, Sonic Hedgehog, Wnt wingless, transforming growth factor, Notch, JAK/STAT, and HippoCRC, have been associated with mutations in these signaling pathway components. The signaling pathways are connected to the development of CRC and give space for deciding how to target certain signaling pathway components in CRC. Numerous initiatives have been made to focus on signaling pathways in order to create fresh treatment strategies. This chapter explains numerous innovative methods with a focus on immunotherapy, targeted therapy, and gene therapy for treating CRC. Here we are focusing on developing novel targeting strategies on signaling pathways as this is the urgent need for secure and efficient medicine delivery to the tumor site.