Abstract
This chapter presents the animal models of allogeneic diseases. There are many similarities between murine allogeneic diseases and human systemic lupus erythematosus (SLE). From an immunopathological point of view, GVH or HVG mice display cutaneous and renal changes resembling those observed in SLE. The spectrum of autoantibodies produced by HVG or GVH mice is very similar to that encountered in human SLE. Furthermore, autoantibodies characteristic of scleroderma are secreted by GVH mice, among them anti-small ribonucleoprotein (snRNP) antibodies, including antifibrillarin antibodies. Incompatibility at I-E locus alone provides the stimulus that leads to the massive formation of autoantibodies characteristic of SLE. Because I-E appears to be the murine analog of HLA-D/DR, this finding is in keeping with the increased frequency of certain HLA-DR alleles in SLE patients. Experimental allogeneic diseases differ, however, from human SLE in some aspects; mice do not display the sex-dependent predisposition and the exacerbations and remissions characteristic of the human disease.
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