Abstract
This chapter presents the mice model of autoimmune vasculitis. The vasculitic lesions in the mouse resemble a small spectrum of human vasculitides. On the one hand, some mouse vessels are infiltrated only by lymphocytes and quite closely resemble the mononuclear vasculitides seen in small vessels of many organs in association with human collagen vascular diseases, such as lupus erythematosis and rheumatoid arthritis. On the other hand, the severe involvement of some vessels, particularly the larger and more muscular vessels in the lungs, with destruction of elastica and a granulomatous-appearing infiltrate, resemble human vasculitides, such as Churg–Strauss syndrome or a Wegner's picture. A separate model from the vasculitis model is developed by coculturing splenocytes with skeletal muscle isolates. This model has not been well characterized but may be important as a model for human autoimmune myositis because it can be produced in 80% of the animals of one strain but not at all in another strain of mouse.
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