Abstract
Phospholipase D (PLD) and phosphatidic acid generated through PLD activity regulate cell survival signal generation, cell migration, apoptosis, and cell invasion. PLD regulates apoptosis and cell invasion through lipase activity-dependent and lipase activity-independent mechanism. Different factors such as serum withdrawal and oxygen level affect the activity of PLD in cancer cells. Phosphatidic acid generated through PLD activity plays an important role in regulating the localization of MT1-MMP to plasma membrane and binding of Akt to the PIP3. PLD mediates the cell migration and survival signal generation through mTOR. PLD interacts with WASp, Grb2, and Rac2 to mediate cell invasion. PLD's role in cell migration, cell invasion, generation of cancer cell survival signal, and antiapoptotic protein expression is discussed in this chapter. In addition, regulators of PLD activity in the cancer cells are also discussed.
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