Abstract
Chemoselective reactions involve two different reactive groups that ideally only react with each other and not with any other functionality present in biological samples or other compounds. The ligation of two chemoselective reactants thus can be carried out within cells, cell extracts, or even in vivo without cross-reactivity with other biomolecules. The bioorthogonal nature of these reactions provides opportunities for highly specific conjugations to be made to label, detect, or deliver certain agents into biological systems. This chapter describes the major reactant pairs that display chemoselective ligation characteristics. Each section reviews the reactions and reagents available to utilize them in bioconjugation procedures.
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