Abstract
Biochemical characterization of a custom expanded bed column made by a nanobiotechnology group was compared with a commercial expanded bed contactor. The hydrodynamic characteristics of the columns (Daxl and Bo) with various settled bed heights along with a variety of column diameters were investigated. All parameters were comparable or superior to those reported for conventional expanded bed contactors. However, the experimental values of Richardson–Zaki coefficient determined here were close to the value of 4.8, commonly used in the laminar flow regimen. The expansion coefficient and terminal velocity of the adsorbent (Streamline DEAE) were theoretically calculated based on the literature and also experimentally determined. The adsorbent was also used in batch binding experiments, as well as in commercial and custom assembled expanded bed contactors with various feedstocks composed of bovine serum albumin and egg albumin. This evaluation exhibited good capacities and adsorption/desorption performance of the NBG column compared with the commercial expanded bed column.
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