Abstract
The liver plays a pivotal role in food and drug metabolism, bile production, detoxification, and regulation of body homeostasis. Liver disease is one of the leading causes of death worldwide. Although liver transplantation is the most effective treatment of last-stage liver diseases, it is limited mainly due to the shortage of donor organs, low degree of engraftment, and need for immunosuppression. Therefore engineered liver tissues that emulate the critical functions of the liver represent the promising platform for studying liver diseases and developing new therapeutics. In particular, three-dimensional (3D) bioprinting technology is advancing rapidly to achieve the goal of successful translation into clinical applications. This chapter describes engineered liver tissues and their applications with a focus on 3D bioprinting strategies and bioinks for the generation of liver tissue constructs. The chapter concludes with challenges and future perspectives for the development of next-generation engineered liver tissues.
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