Abstract
Genetically, engineered probiotic organisms are envisioned as the next new age functional products. The concerted ability of the engineered probiotic strains designed to recognize the target, synthesize, and deliver biomolecules at a specific site has made them popular biotherapeutics. Several evidences discussed in this chapter confirm the potential application of genetically modified probiotic strains in numerous conditions ranging from irritable bowel syndrome to hypertension to phenylketonurea to tumor therapy to antiinfectives. In the future, the tools of Clustered Regularly Interspaced Short Palindromic Repeats can be further modified to develop a diverse range of designer probiotic strains by swapping the promoter and therapeutics genes to target several other disease biomarkers and treatments, respectively. Considering the growing application of probiotics as biotherapeutics, the chapter also discusses some of the emerging techniques for microencapsulation of probiotic strains.
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