Abstract
The rapid advance in the field of nanotechnology especially in nanopharmaceutics have led to the development of a discipline called nanotoxicology. Various European, US (ISO, OECD, etc.), and Japanese regulatory agencies have some guidelines in the field of pharmaceutical toxicology, but there is an emergency need for the guidelines revision in the field of nanotoxicology due to size influence. It is interesting to note that there are efficient standard analyses for chemical and pharmaceutical drugs in the field of genotoxicity. However, some of them will not be efficient in nanotoxicology such as Ames (OECD 471), although in other toxicology analyses, it seems that just more attention in some pathways is enough. For example, in hemocompatibility tests with more emphasis in the complement system. Overall, although the nanopharmaceutical drugs have attracted high impact in the cancer or other therapies but attention to the eventually hidden side effects derived from them is necessary.
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