Abstract
This chapter discusses human histocompatibility (HL-A) antigens, which are described as membrane-associated transplantation antigens. The HL-A antigens are associated with a variety of biological phenomena, and have the property of eliciting an immune response by the host following transplantation of allogenic organs and tissues. The cytotoxicity reaction depends upon alteration in permeability induced by the action of complement on cells which have been exposed to anti-HL-A antibodies. The sources of antisera reacting with human histocompatibility antigens are multiparous women, transfused and sensitized patients, and human volunteers immunized with skin grafts, leukocytes, or platelets. An additional advantage of the quantitative absorption of HL-A alloantisera is that it affords a comparison of the densities of different HL-A determinants located on the same cell and of the same HL-A specificity present on fibroblasts derived from different individuals. A further application of this technique might be for the quantitation of HL-A antigens on normal and transformed human diploid fibroblasts.
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