Abstract
The following chapter summarizes the current knowledge about the slow vacuolar (SV) cation current and two-pore channels (TPCs) in plants and animals. TPCs are ubiquitously expressed in plant vacuoles and the animal endolysosomal system. Evolutionary aspects of TPCs in the plant and animal kingdoms will be discussed. Differences in plant and animal TPC regulation and the main functional domains in both homologs are compared. Finally, the long-lasting cross kingdom debates over the contribution of TPCs to calcium signalling is summarized.
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