Chapter 13 - Osteogenesis Imperfecta

Abstract

Osteogenesis imperfecta (OI) is an inherited disorder of connective tissue resulting in bone fragility, muscle weakness and joint hypermobility. OI has an incidence of 1 in 10,000–25,000 births. This disorder is marked by recurring fractures, which can be sustained from even minimal trauma. When coupled with weak muscles and lax joints, the major deformity can result in major. Additional impairments in OI with variable presentation include blue sclerae, dentinogenesis imperfecta, deafness, hernias, easy bruising, and excessive sweating.