Abstract
Arthrogryposis multiplex congenita (AMC) is a nonprogressive neuromuscular disorder characterized by joint contractures and often associated muscle weakness. It is a symptom with over 200 types of arthrogryposis having been identified with over 400 genes contributing to it. Despite all of the aggressive genetic work being done on AMC at this time, nearly 40% of the cases do not have an identified genetic difference. In this chapter, we will discuss testing for AMC, orthopedic intervention, and therapy strategies across the life span.
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