Abstract
Nanostructured drug delivery systems (DDS) represent a revolution in the release of drugs, improving their efficiency and reducing toxicity. However, a single DDS cannot fulfill all drug release requirements. Hybridization, resulting in systems that combine the properties of their constituents, resembles an alternative to improve DDS capacity to release active molecules with higher efficiency and specificity. Biohybrid materials (inorganic nanocarrier in organic matrices) have been studied for the last 30years as DDS, but another class of biohybrid DDS, composed only of organic excipients, the organic-organic biohybrid (ORG-HYB) systems, deserves attention. Such versatile DDS may combine lipid-polymer, protein-polymer, and polymer-polymer components. Typically, different nanoparticles are incorporated in a polymer matrix, being processed as a functional pharmaceutical form joining the advantages of both materials, to provide sustained release, adhesiveness, permeation enhancement, and drug targeting. Smart ORG-HYB responds to stimuli (temperature and pH), increasing tissue specificity and/or discharging drugs in a controlled manner.
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