Abstract
Ocular drug delivery has remained as one of the most challenging task for pharmaceutical scientists. Compared with drug delivery to other parts of the body, ocular drug delivery has met with significant challenges posed by various ocular barriers. Effective treatment of ocular diseases especially in posterior ocular segments is a challenging task for formulation scientists because of the various barriers rendered by anatomy and physiology of the human eye. Much of the emphasis has been given to achieve noninvasive sustained drug release for eye disorders in both segments. Many polymeric systems utilizes viscosity modification, mucoadhesion, and in situ gelling for prolonging retention time, and reducing administration frequency have been developed for anterior drug delivery segment of the eye. On the other hand, biodegradable and nonbiodegradable polymeric implants for sustained drug delivery for chronic vitreoretinal diseases have been developed. Colloidal polymeric carriers are increasingly being studied for their applications. This chapter thoroughly discusses different drug delivery systems that utilizes polymers in ocular drug delivery.
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