Abstract
This chapter describes the current understanding of a wide variety of platelet pathology, including thrombocytopenia, thrombocytosis, qualitative platelet disorders, and diagnostic approaches to these problems. Neonatal autoimmune and alloimmune thrombocytopenia, immune thrombocytopenia in the older child, as well as other acquired causes of thrombocytopenia, including thrombotic thrombocytopenic purpura (inherited and acquired), are described. Classical therapeutics and new agents like the thrombopoietics are reviewed. The discussion of thrombocytosis includes secondary causes of thrombocytosis and familial and hereditary thrombocytosis. Qualitative platelet disorders, including various inherited disorders of platelet function and secondary causes of platelet impairment (e.g., drugs), are described. It also includes a section focused on diagnostic tests for platelet function.
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