Abstract
Genetic mapping has identified several candidate variants in autoimmune conditions; however, thyroid autoimmune diseases cannot be explained by genetic susceptibility alone. In monozygotic twins, the concordance for most autoimmune diseases is only 20%–30%, indicating that epigenetics and environmental factors may also be determinant. Epigenetics refers to inheritable and potentially reversible changes in DNA and chromatin, which regulate gene expression without altering the DNA sequence. Epigenetic regulation includes DNA methylation, histone modification, and noncoding RNA-mediated regulation. Epigenetic mechanisms regulate gene expression levels, and their impairments result in networks of genes that are switched on or off, thus contributing to disease pathogenesis. This chapter describes the contribution of epigenetics to autoimmune thyroid disorders.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
