Abstract
From the advent of genome sequencing and assembly in to the 1970s to the present day a great deal has been achieved in genome science. We now have the experimental means, tools and computing hardware necessary to successfully sequence and assemble large complex genomes. However challenges remain and draft genome sequences are widely known to contain misassemblies, largely due to repetitive DNA. As technology advances, new ways to generate large amounts sequence data in a short time and the increasing use of low-coverage genome scans are resulting in a greater reliance on bioinformatics tools for sequence assembly and comparison. With these new directions in genome science, this research area will remain as an active one for some time.
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