Abstract
Surface-enhanced Raman spectroscopy (SERS) is an interesting techniques and has garnered increasing attention in the scientific community since its discovery. The optical nanosensor has been designed to utilize the sensitivity of SERS for making the quantitative and qualitative measurements. This chapter introduces a multifunctional and optical nanosensor based on SERS and presents their utility in innovative applications in the biomedical and biomarker space. The optical nanosensor has been improved with the incorporation of gold and silver nanoparticles in the SERS experiment. The nanosensor images and detects based on the SERS technique. In this chapter, we have focused on previously reported studies with promising trends that have been highlighted less frequently. The optical nanosensor has been designed to utilize the sensitivity of SERS for the intracellular environment using small devices. The use of biomarkers is emerging as one of the most attractive methods for understanding biological and living cell applications. The detection limits for biomarkers used for the various applications in colorimetric, fluorescence, Raman spectroscopy for recent applications. However, we discuss the most recent biomedical and biomarker applications based on SERS techniques.
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