Abstract
This chapter discusses the myosin light-chain phosphatase (MLCP). Smooth muscle contains many protein phosphatases, as expected for any eukaryotic cell, and several of these have been shown to use phosphorylated myosin as substrate. Whether myosin is a native substrate is not known, but the possibility that more than one phosphatase act on myosin cannot be excluded. However, if the criterion is that the relevant phosphatase should be associated with—that is, bind to—the contractile apparatus, the possibilities are more restricted. The consensus is that the myosin-bound phosphatase is a type I enzyme and the catalytic subunit has been identified as the 8-isoform. In addition, several groups have shown that a trimeric enzyme is associated with myosin and the possibility of targeting subunits has been raised.
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