Chapter 10 - Indazole as a privileged scaffold in drug discovery

Abstract

Indazole is a type of bicyclic heterocycle that has unique chemical and pharmacologic properties and has been recognized as a privileged scaffold in drug discovery. In this chapter, we briefly summarize synthetic approaches to indazoles and their medicinal partnership in drug discovery. Indazoles have been widely used as core structures and crucial pharmacophores in drug design and lead compound optimization. Their therapy treatments include anticancer and respiratory , infectious , neurological, and cardiovascular disease. We attempt to introduce the chemical space of indazoles to fit the divergent biological space and facilitate efficient drug discovery.