Abstract
The cell of origin of the different histotypes of epithelial ovarian cancer (EOC) has been debated for some time. The dogma for nearly 50 years has been that EOCs develop from the ovarian surface epithelium (OSE), a single layer of mesoepithelial cells with multipotent properties. More recently, evidence suggests that the most common EOC histotype, serous, might develop predominantly from mutated secretory cells at the fimbriated end of the fallopian tube, but another extra-ovarian source has also been proposed, as well as nonovarian sources for endometrioid, mucinous, and clear cell types. This chapter will describe the evidence supporting both the OSE and these extraovarian sources as sites of origin for EOC.
Published Version
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