Changes of thrombin-antithrombin complex and other variables in acute respiratory distress syndrome

Abstract

Objective To measure D-Dimer(DD) ,thrombin-antithrombin complex(TAT), lasmin-antiplasrain complex(PAP) and protein C(PC) in ARDS,to find the clinical significance of them,discuss the objective base in the early diagnosis of ARDS in the lab, and offer the serologic bases in the treatment and prognosis of ARDS.Methods 105 patients of ARDS were selected as the study group, and 105 people were selected as the control group, all of whom were healthy with no thrombus diseases. The venous blood of everyone in both groups was sampied,in order to take a quantitative determination of plasma prothrombin time(PT), prothrombin time(TT), kadin partial thromboplastin time(APTT), the amount of blood platelet, DD, TAT, PAP, PC. Results Serum concentratation of D-D, TAT, PAP was significantly higher in patients in ARDS group than that in control group(P＜0.01).Serum concentratation of PC was significantly lower in patients in ARDS group than that in control group (P＜0.01). Conclusion Measuring the concentration of DD, TAT, PAP and PC was very important, which not only did good to the early diagnosis of ARDS,but also had a clinic value. Key words: Respiratory distress syndrome,adult; Pyrimidine dimers; Thrombin; Antithrombins