Abstract
ABSTRACT: This study assessed changes in the levels of adenosine deaminase (ADA) and its isoenzymes in addition to routine liver biochemical parameters in sheep with fascioliasis. The study was conducted on 35 Akkaraman sheep. Of these, 25 sheep were diagnosed with fascioliasis based on anamnesis and clinical signs, and had endoparasites based on parasitological examinations (Fasciola-infected group). The remaining 10 sheep that were sampled from a single healthy herd (same flock) different from the infected group did not have any clinical signs or endoparasites (control group). Total protein (TP), albumin (ALB), and globulin (GLB) levels gradually increased on days after treatment compared to the values measured before treatment; the increases were statistically significant on all days for TP levels but only on day 14 after treatment for GLB levels (P < 0.05). Although, the ALB levels did not increase significantly on days after treatment, the ALB level and ALB/GLB ratio on days 7 and 14 after treatment were still lower than the values of day 21 after treatment and control group (P < 0.05). Total bilirubin (T-Bil) and direct bilirubin (D-Bil) levels on days 14 and 21 were significantly lower than that of day 0 (before treatment) and day 7 after treatment (P < 0.05). These results indicated that the increase in adenosine deaminase (ADA) and ADA1 levels may be due to possible concomitant infection of Fasciola larvae (in the parenchyma) and adults (in the bile duct).
Highlights
Fascioliasis is a zoonotic disease caused by the trematode Fasciola hepatica, the most common liver fluke
Clinical fascioliasis can be classified as acute, subacute, or chronic according to the number and stage of flukes present in sheep (MITCHELL, 2002; ROJO-VÁZQUEZ et al, 2012)
Subacute fascioliasis is an advanced stage that follows the acute form; it can be fatal, with many juvenile flukes being present in the liver parenchyma and many adult flukes being present in the bile ducts (MITCHELL, 2002; ROJO-VÁZQUEZ et al, 2012)
Summary
Fascioliasis is a zoonotic disease caused by the trematode Fasciola hepatica, the most common liver fluke. V.52, n.4, Editors: Rudi Weiblen Rudiger Daniel Ollhoff fascioliasis is the parenchymal phase characterized by acute liver failure. It is often accompanied by hemorrhage due to parenchymal damage caused by the migration of several juvenile flukes (which are large enough to cause mechanical damage to the liver) after the ingestion of several metacercariae (MITCHELL, 2002; IBRAHIM, 2017). Laboratory findings vary according to the stage of the disease anemia, eosinophilia, hypoalbuminemia, and increased liver enzyme levels are commonly detected in infected sheep (MITCHELL, 2002; ROJO-VÁZQUEZ et al, 2012; IBRAHIM, 2017)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
