Changes in platelet activity during perioperative period in patients with diabetes mellitus

Abstract

Objective To evaluate the changes in the platelet activity during the perioperative period in the patients with diabetes mellitus. Methods Twenty patients with type 2 diabetes mellitus (group DM) and 22 patients with no diabetes mellitus (group NDM) of both sexes, with body mass index of 20-30 kg/m2, of American Society of Anesthesiologists physical statusⅠ or Ⅱ, scheduled for elective spinal or hip joint surgery, were enrolled in the study.Blood samples were collected on admission to the operating room (T0), immediately after recovery from general anesthesia (T1) and at 24 h after surgery (T2). The expression of platelet P-selectin (CD62P) was measured by flow cytometry, and the positive rate was calculated.The platelet count (PLT) and mean platelet volume (MPV) were determined using an automatic blood cell analyzer. Results Compared with group NDM, the positive rate of CD62P cells at T0, 1 and PLT at T0 were significantly increased (P 0.05). There was no significant difference in the positive rate of CD62P cells, PLT or MPV between each time point within each group (P>0.05). Conclusion Platelets remain hyperactivity that is not further enhanced by diabetes mellitus during the perioperative period in the patients. Key words: Diabetes mellitus; Intraoperative period; Blood platelets