Abstract
The isozyme spectrum of hexokinase (HK) of the mucous membrane of the rat large intestine consists of three isozymes. In tumors induced by 1,2-dimethylhydrazine in this situation, the isozyme composition of HK is simplified through the loss or sharp reduction in content of the isozyme with the fastest speed of migration toward the anode. In metastatic tumors HK is represented by a single isozyme. The Michaelis constant (glucose) for KG in the tumors is reduced by 2–3 times. Starting from the first month of administration of the carcinogen, HK activity begins to appear in the blood serum of the animals and by the fifth month it is found in 80% of cases. HK was always absent from the blood serum of control animals.
Published Version
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