Changes in Neuronal Antibody and S100β Protein Content as a Risk Factor for Occupational Neurointoxication

Abstract

The production of the vinyl chloride (VC) still extremely popular in many countries of the world today. The aim of this research was to study changes in the content of S100β protein and antibodies to nerve tissue proteins as regulators of the nervous system in workers in the production of vinyl chloride, depending on the severity of the pathological process. Men working in the production of VC were examined. There are 53 healthy trained workers without signs of disorders of neuro-mental status and 26 patients with initial manifestations of neurointoxication with vinyl chloride among them. The concentration of S100β protein and neurotrophic antibodies (NAB) in blood serum was determined by solid-phase enzyme immunoassay. The more pronounced increase in S100β protein was found in persons with initial manifestations of neurointoxication, compared with trained healthy workers. The involvement of autoimmune reactions in the processes of regulation of the nervous system through the production of antibodies (AB) to certain structures of the nervous tissue has been proved. It is shown that the intensity of autoimmune reactions and the spectrum of produced AB working in the production of VC depend on the duration of exposure and the stage of development of the neurointoxication. It was also established that the change in the synthesis of NAB to specific proteins of nervous tissue is associated with the deterioration of neurological status in trained healthy workers. The obtained results allow us to assess the degree of interest of certain structures of the nervous tissue – bioregulators of the nervous system in the development of neurological disorders. Revealed an increase in serum concentrations of NAB to MAG, and in persons with clinical manifestations of asthenic disorder with autonomic dysfunction – NAB to DNA, NAB to S100β in trained healthy workers. These indicators can be regarded as a risk factor for occupational neurointoxication. The results obtained will improve the quality of diagnosis, especially in the early stages of the disease and, as a result, the formation of the most optimal treatment tactics.