Abstract
The activity of an endonuclease (deoxyribonucleate oligonucleotidohydrolase, EC 3.1.4.5) which preferentially hydrolyses native DNA has been examined during the regeneration of rat liver. The activity of this enzyme increased 2–3-fold prior to the initial post-operative peak of DNA synthesis and remained elevated for at least 70 h. The control levels of activity seen in the sham-operated animals and at 4 h following partial hepatectomy indicate that the observed increase is not due to a shock reaction.
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