Abstract
目的 探讨血清人附睾蛋白4(HE4)、人软骨糖蛋白-39(YKL-40)水平在子宫内膜癌患者中的变化及临床意义.方法 应用酶联免疫吸附法检测60例子宫内膜癌、57例子宫内膜增生患者血清HE4、YKL-40水平,并以60例健康体检者作对照.结果 子宫内膜癌组血清HE4、YKL-40水平分别为(214.75±35.36)pmol/L,(99.16±21.39)μg/L,显著高于子宫内膜增生组的(54.23±11.46)pmol/L,(40.58±9.63)μg/L,差异有统计学意义(t=32.88,18.31,均P 0.05);相关性分析表明,HE4与YKL-40表达呈显著正相关(r=0.715,均P<0.01).结论 HE4、YKL-40可作为子宫内膜癌血清学标志物,在子宫内膜癌中的过度表达可能与其发生和发展有关,为判断子宫内膜癌的早期辅助诊断、疗效评估的重要指标之一。
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