Change of serum tumor markers and short-term efficacy after radiotherapy in advanced non-small cell lung cancer patients

Abstract

Objective To investigate the change of the serum levels of CEA,CYFAR21-1,SCC,CA125 in advanced non-small cell lung cancer.patients before and after radiotherapy retrospectively and to explore the relationship between the change of serum tumor markers and the short-term efficacy of radiotherapy.Methods The serum levels of CEA,CYFAR21-1,SCC,CA125 in 205 cases with advanced non-small cell lung cancer were detected (by electro-chemiluminescence immunoassay method)before and after radiotherapy,and the short-term efficacy of radiotherapy was assessed (RECIST 1.1 edition) at the same time.The changes in tumor markers and the short-term efficacy were analyzed.Results Totally 113 patients achieved response of short-term efficacy after radiotherapy,and the effective rate of the short-term efficacy was 55.1％.Among these 113 patients,the serum levels of tumor markers decreased significantly after radiotherapy(t =3.224,2.896,3.137,3.219,P ＜ 0.05).The serum levels of tumor markers in patients with stage Ⅲ and Ⅳ decreased after radiotherapy (t =2.484,2.445,2.148,2.109,P ＜ 0.05 ;t =2.072,2.857,2.277,2.436,P ＜ 0.05).Among 92 patients who did not achieve response of short-term efficacy,the serum level of tumor markers increased significantly after radiotherapy(t=2.224,2.005,2.261,2.545,P ＜ 0.05).For the patient who achieved response of radiotherapy with tumor markers decreased,the short-term efficacy was significantly better than the group of which tumor maker increased (x2 =80.001,P ＜ 0.01).Conclusions The serum levels of CEA,CYFAR21-1,SCC,CA125 can be used for assessment of short-term efficacy after radiotherapy in advanced non-small cell lung cancer patients. Key words: Tumor marker; CEA; CA125 ; CYFAR21-1 ; SCC ; Radiotherapy; Nonsmall cell lung cancer