Abstract
Berberine (BBr), a natural isoquinoline alkaloid, has pharmacological activities such as anti-inflammatory, analgesic, antimicrobial and antitumor effects. However, the low bioavailability of BBr has restricted its applications. This study is aimed to fabricate berberine nanoparticles by roll milling method to enhance their bioavailability and study their anticancer activities. For the characterization of berberine nanoparticles, Field Emission Scanning Electron Microscopy (FE-SEM), Transmission Electron Microscopy (TEM), Dynamic Light Scattering (DLS), X-ray Diffraction (XRD) and Ultraviolet – visible spectroscopy (UV-Vis) were employed. The results showed that berberine nanoparticles average diameters were 60 nm after 120 hours roll milling with the support of Zirconia beads. Cytotoxicity assessments indicated that Nano BBr inhibited breast cancer (MCF-7) and hepatic cancer (Hep G2) cells growth.
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