Abstract
Genotyping of 64 children of the main group with combined with type 1 diabetes mellitus (type 1 diabetes) autoimmune diseases (autoimmune thyroiditis (AIT) and/or celiac disease) and 135 pediatric patients of the comparison group with isolated type 1 diabetes mellitus was performed by predictor gene alleles not related to HLA: CT60 (+6230G>A) (rs3087243), c.49A>G (rs231775) of the cytotoxic T lymphocyte antigen-4 (CTLA4) gene, c.1858C>T
 (rs2476601) of the tyrosine phosphatase lymphocyte (PTPN22) gene, a microsatellite repeat in exon 5 of the gene of non-canonical histocompatibility class I MICA molecules. In patients with combined AIT type 1 diabetes mellitus, an association was established between the c.49AA genotype (rs231775) and the A allele at the CT60 (+6230G>A) (rs3087243) loci of the CTLA4 gene with the risk of transient antibodies to gliadin. In all groups of patients, the MICA 5.1 STR allele prevailed. The presence of the MICA A5.1/ A5.1 homozygous genotype in patients with type 1 diabetes doubles (OR = 2.13, 95% CI: 1.0003-4.5321, P = 0.0499) the risk of AIT development.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
