Abstract
Tumor metastasis is a multistep process, including local invasion, intravasation, transport, extravasation, and colonization. For tumor cells to disseminate from their primary site and form secondary tumors at a distant site, they need to activate a number of cellular programs, including epithelial–mesenchymal transition (EMT), invadopodia-mediated ECM degradation, various modes of cell migration, as well as resistance to anoikis and microtentacle-mediated endothelium attachment. Here, we review the most widely accepted findings relevant to individual cellular processes and discuss their importance during tumor invasion and metastasis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
