Abstract
Recent studies emphasize the pervasive function of intercellular adhesion and its interplay with cortical tension in biological processes such as morphogenesis, wound healing, and cancer metastasis. However, quantifying such interaction at single-cell level is challenging and results are dependent on experimental conditions. Most interrogations focus on collective behavior of cells or are performed in the presence of cell-ECM or cell-substrate adhesion. Thus, the interaction of cytoskeletal protein complexes with adhesion components and tension-adhesion regulation is not well clarified.
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