Abstract
The data from this multicenter comparison of oral cefetamet pivoxil (CAT) (10 and 20 mg/kg twice daily) and amoxicillin plus clavulanic acid (30 to 50 mg/kg/d, in three divided doses) in the treatment of acute (recurrent) urinary tract infections (UTIs) in children are reported. A total of 421 children (aged 2 months to 15 years) were treated for 7 to 10 days. At follow-up (day 28), there was bacteriologic success (eradication or reinfection) in 97% of those treated with CAT and in 93% of those treated with amoxicillin plus clavulanic acid. The overall cure rate was 97% for CAT and 93% for amoxicillin plus clavulanic acid. There was no difference in outcome between the two CAT dosages. With both drugs adverse events were gastrointestinal in nature. CAT is an appropriate drug for the treatment of acute UTIs in children, being at least as effective as amoxicillin plus clavulanic acid.
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