Abstract
C/EBP and the Control of Phosphoenolpyruvate Carboxykinase Gene Transcription in the Liver
Highlights
Transcriptional Regulation of the phosphoenolpyruvate carboxykinase (PEPCK) Gene Promoter The transcriptional control of the gene for the cytosolic form of PEPCK from the rat [7,8,9] and chicken [10, 11] has been extensively studied
Because the sequence of the promoter for the PEPCK gene from the mouse, rat, and human has been remarkably conserved, it is reasonable to assume that the pattern of transcriptional regulation noted from studies with the PEPCK gene promoter from rodents is characteristic of the control in most mammalian species
We have demonstrated that NFI inhibits transcription from the PEPCK gene promoter and suggested that an interaction between NFI and cAMP regulatory element-binding protein (CREB)-binding protein (CBP) is involved in the control of the basal level of transcription of the PEPCK gene in the liver [20]
Summary
Transcriptional Regulation of the PEPCK Gene Promoter The transcriptional control of the gene for the cytosolic form of PEPCK from the rat [7,8,9] and chicken [10, 11] has been extensively studied. We have demonstrated that NFI inhibits transcription from the PEPCK gene promoter and suggested that an interaction between NFI and CREB-binding protein (CBP) is involved in the control of the basal level of transcription of the PEPCK gene in the liver [20].
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