Abstract
Metal-proline complexes of various metals like Zn, Cd, Hg, and Pb were found to be good catalysts for direct Mannich reaction in water medium at room temperature, smoothly affording the β-amino carbonyl compounds in excellent yields. Among the catalyst cadmium-proline complex gave high yield in lesser time. All the catalysts were easily separated from the reaction mixture by water extraction and among this cadmium -proline complex was found to be most stable and can be recycled five times without losing its catalytic activity.
Highlights
The development of catalytic multi-component reactions in water medium has become the most challenging area in the current chemistry [1,2,3,4]
In continuation of our ongoing studies on the synthesis of new variants of metal-proline complexes and to investigate the catalytic activities in water medium, here we report the use of metal-proline complexes for one-pot three component Mannich reactions and the possibility of catalyst recycling
X-ray patterns of the prepared metal-proline complexes were recorded at 2Ɵ=0-100 range and are shown in figure 1
Summary
The development of catalytic multi-component reactions in water medium has become the most challenging area in the current chemistry [1,2,3,4]. In the modern version of the Mannich reaction, many drawbacks have been developed by using water as reaction medium in presence of catalyst in one step process of one-pot three component strategy. Most of the researchers explored Mannich reaction using water as a reaction medium in presence of a catalyst with high yields and enantioselectivities. Barbas and Cordova explored the Mannich type reaction in H2O/THF medium by using L-proline as organocatalyst for the reaction [18]. Our recent interest has been focused on the development of metal-proline complexes as organocatalysts for organic reaction in water medium. In continuation of our ongoing studies on the synthesis of new variants of metal-proline complexes and to investigate the catalytic activities in water medium, here we report the use of metal-proline complexes for one-pot three component Mannich reactions and the possibility of catalyst recycling
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