Bi(NO3)3•5H2O-catalyzed Mannich Reaction: A Potent Catalyst for Synthesis of β-Aminocarbonyl Compounds

Abstract

Biologically active compounds containing nitrogen, natural molecules and drugs are important for organic synthesis. Mannich reaction is one of the most common methods used for the synthesis of these compounds. Bi(NO3)3 was used as an efficient catalyst for the one-pot three-component Mannich reactions of ketones with different aromatic amines and aromatic aldehydes at room temperature. It is a good method to prepare β-amino carbonyl compounds in excellent yield. The high efficiency using simple starting materials and a catalytic amount of a reusable catalyst is especially noteworthy.