Cation exchange resin in treatment of the nephrotic syndrome.

Abstract

THE USE of cation exchange resin for the relief of edema was first suggested by Dock 1 in 1946. Since that time, several studies have been performed on animals 2 and on man 3 with results that were summarized by Dock 4 in 1950. These experiences have indicated that treatment with the cation exchange resin is of real value in the control of cardiac edema and edema from other sources. However, difficulty has arisen from several sources during the administration of resin. This paper deals with the observation of effects and toxicity of cation exchange resin in 14 patients with the nephrotic syndrome, treated during a period of one year. It is a compilation of several experiences which have demonstrated the striking benefits that may accrue to the nephrotic patient from resin administration and also the danger of the severe toxicity that may occur. METHODS AND MATERIALS The cases of