How safe is cation exchange resin therapy when used in private practice? A clinical study and parallel laboratory study.

Abstract

Article1 June 1954HOW SAFE IS CATION EXCHANGE RESIN THERAPY WHEN USED IN PRIVATE PRACTICE? A CLINICAL STUDY AND PARALLEL LABORATORY STUDYCHARLES WILLIAM SMITH, M.D., F.A.C.P., KENNETH E. QUICKEL, M.D., F.A.C.P., ARTHUR E. BROWN, M.D., CHESTER G. THOMAS, M.D.CHARLES WILLIAM SMITH, M.D., F.A.C.P.Search for more papers by this author, KENNETH E. QUICKEL, M.D., F.A.C.P.Search for more papers by this author, ARTHUR E. BROWN, M.D.Search for more papers by this author, CHESTER G. THOMAS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-40-6-1169 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMost clinicians1, 2, 3 who first investigated cation exchange resins to control edema tempered their enthusiasm for this therapy with precautions. Although they found that such resins removed sodium and thereby effectively reduced extracellular fluids, they recommended that patients taking them be followed with many chemical tests. Their precautionary recommendation appeared necessary because of the effect of the resins on electrolyte balance.The following complications1, 4, 5, 6, 7, 8, 9have been noted in the literature. Acidosis, a not infrequent disturbance, was noted early in the use of resin therapy. These early resins exchanged hydrogen ions for the positive...Bibliography1. IrwinBergerRosenbergJackenthal LEYBR: The effect of a cation exchange resin on electrolyte balance and its use in edematous state, J. Clin. Investigation 28: 1403-1411, 1949. CrossrefMedlineGoogle Scholar2. Kraus H: The use of a cation exchange resin in patients with cardiac edema, J. Clin. Investigation 29: 829, 1950. MedlineGoogle Scholar3. DanowskiGreenmanPetersMateerWeigandTarail TSLJHFMFAR: The use of cation exchange resins in clinical situations, Ann. Int. Med. 35: 529-541, 1951. LinkGoogle Scholar4. Lippman RW: Cation exchange resin in treatment of the nephrotic syndrome, Arch. Int. Med. 88: 9, 1951. CrossrefGoogle Scholar5. DockFrank WNR: Cation exchangers: their use and hazards as aids in managing edema, Am. Heart J. 40: 638, 1950. CrossrefMedlineGoogle Scholar6. FeinbergRosenberg AWB: The use of a carboxylic cation exchange resin in the therapy of congestive heart failure, Am. Heart J. 42: 698, 1951. CrossrefMedlineGoogle Scholar7. CallahanFrankKrausEllis EJNRHLB: Clinical use of cation exchange resins in the treatment of congestive heart failure, Am. J. M. Sc. 223: 117-125, 1952. CrossrefMedlineGoogle Scholar8. ChapmanPannillSkaggs DWFCRH: A new cation exchange resin in the therapy of edematous states, Am. Pract. and Digest Treat. 2: 945, 1951. MedlineGoogle Scholar9. GreenmanShalerDanowski LJBTS: Biochemical disturbances and clinical symptoms during prolonged exchange resin therapy in congestive heart failure, Am. J. Med. 14: 391-403, 1953. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Harrisburg, Pennsylvania*Received for publication July 3, 1953.From the Harrisburg Clinic, Harrisburg, Pennsylvania.Presented in part before the Postgraduate Institute of the American College of Physicians, Hahnemann Medical College, Philadelphia, May 13, 1952. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTherapie der Herzinsuffizienz 1 June 1954Volume 40, Issue 6Page: 1169-1176KeywordsCationsEdemaResearch laboratoriesSodium ePublished: 1 December 2008 Issue Published: 1 June 1954 PDF downloadLoading ...