Catalytic enantioselective protonation of a samarium enolate with fluorous chiral and achiral proton sources in fluorous biphasic systems

Abstract

Enantioselectivities near maximum values were obtained in the catalytic reaction by a ropid addition of a fluorous achiral alcohol (Rfh 3COH) to the reaction mixture: for DHPEX in Rfh 3COH/THF solid-liquid biphase system and for a fluorous chiral alcohol in THF/FC-72 liquid-liquid biphase system.