Abstract
The purpose of this study was to examine the diuret ic effect of the aqueous extract of Capparis spinosa (Cs) at a dose of 500 mg kg -1 h -1 in normal rats. The aqueous extract was administred intravenously and the diuresis was foll owed within four hours after starting the treatment . Intravenous administration of aqueous Cs extract pr oduced a significant increase on diuresis (p<0.001) and glomerular filtration rate from the second hour of treatment to the fourth hour (p<0.001). In addition, urinary Na+, Cl- and K + were significant ly increased after two hours of Cs perfusion (p<0.01). Furosemide at a dose of 0.1 mg kg -1 h -1 had similar effect when compared to Cs administration. We conclude that the water extract of Cs fruit exhibited a significant diuretic effect accompanied by in crease in Na+, K+ and Cl- urinary excretion in normal rat. This effect may be mediated via a Furosemide like effect.
Highlights
Increasing diuresis phenomena might be a useful tool in the treatment of hypertension[1]
This study aims to evaluate diuretic effect of continuous intravenous perfusion of aqueous Capparis spinosa (Cs) extract in anaesthetized rats
Effect on Glomerular Filtration Rats (GFR): Perfusion of aqueous Cs extract during two hours caused a significant increase in Glomerular Filtration Rate (GFR), as estimated by creatinine clearance (p
Summary
Increasing diuresis phenomena might be a useful tool in the treatment of hypertension[1]. Medicinal plants was commonly used for traditional treatment of some renal diseases[2]. Many investigations have demonstrated the hypotensive effect of several plants with a diuretic activity[3,4,5,6,7,8,9,10,11]. The use of diuretic plants in the treatment of hypertension may be beneficial in the reduction of blood pressure and kidney damage associated with hypertension. Cs fruit is used in the folk medicine for its hypoglycaemic[13,14] diuretic, antihypertensive and tonic properties[15]. This study aims to evaluate diuretic effect of continuous intravenous perfusion of aqueous Cs extract in anaesthetized rats
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